Here’s What You Need To Know About L-Theanine (2024)

If you deal with daily stress or trouble sleeping, you’ve probably turned to a hot cup of tea to settle your nerves. Indeed, there’s good reason tea has a reputation for being so comforting. Research shows that tea can help with everything from lowering cholesterol to improving gut health.

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So, it’s natural to think about the ingredients in tea that make it so beneficial. Enter L-theanine — an amino acid that’s present in tea leaves. It’s also used as a supplement, as it may help with anxiety and sleep conditions.

Dietitian Julia Zumpano, RD, LD, talks about what l-theanine is and what you should know before you consider taking it.

What is L-theanine?

L-theanine is an amino acid found in tea leaves, particularly green tea and loose-leaf tea, that has several potential health benefits. But first, let’s go over what amino acids are and why they’re important.

“Amino acids are proteins and they’re really the building blocks of our life,” explains Zumpano. “Amino acids are molecules used by all living things to make proteins. In total, we as humans need 20 different amino acids to function properly. But there are those 11 essential amino acids that our body really needs to get through food.”

While L-theanine isn’t essential for our survival, its presence in plants and fungi has been studied for its possible impact on our brain function.

L-theanine can be taken by drinking certain teas like green teas, white teas or matcha. It can also be taken as a tablet or pill form.

Benefits of L-theanine

But if you’ve looked up the benefits of L-theanine, you may have started to scratch your head. Some proponents claim it can help you feel more alert, while others say that it can help with insomnia. So, which is it? As Zumpano points out, the best way to get the most use out of L-theanine has a lot to do with when you’re taking it and what you’re pairing it with.

It’s also important to know that these effects may vary from person to person and that there’s still limited research on the benefits of taking L-theanine to help with mental and cognitive issues.

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Here are some of the explored benefits of L-theanine:

Improving sleep quality

You may have heard that taking L-theanine before bed can help if you experience disruptive sleep or have trouble falling asleep. A 2019 study explored the benefits of an L-theanine and GABA supplement combination on sleep quality and length. GABA, short for gamma-aminobutyric acid, is a naturally occurring chemical messenger in your brain that’s been linked to creating a calming effect. It’s also available as a dietary supplement. The study showed that this combination could potentially increase sleep duration and REM sleep.

According to Zumpano, if you’re looking to try L-theanine in tea or supplement form, it’s a good idea to take it in the evening before going to bed and not pair it with any coffee or caffeinated beverage. If you’re experiencing more serious sleep issues like insomnia or sleep apnea, L-theanine likely won’t do the trick.

Also, you should ask your healthcare provider before pairing any prescription medications with L-theanine before bed. L-theanine can be safely taken with melatonin, however.

Reducing stress and anxiety

Remember how a cup of tea can calm you down after a hectic day? Research shows that L-theanine supplements can elevate your levels of GABA, dopamine and serotonin, which promotes relaxation and reduces anxiety levels.

A randomized trial from 2019 found that healthy adults who took L-theanine over the course of four weeks had a decrease in stress-related symptoms. While these results are promising, it’s important to remember that stress reduction will look different for everyone, depending on what stress response you’re having and when you’re experiencing it.

Boosting mental clarity

If you’re feeling brain fog or a general blah feeling, L-theanine may be able to help give you a boost of mental clarity and enhance your ability to focus. According to the same 2019 study, L-theanine helped healthy adults with verbal fluency and the ability to stay focused. The benefits are heightened when taken with caffeine.

“If you’re going to take L-theanine to gain more alertness and mental clarity, you should take it during the day,” advises Zumpano. “It does seem to do better with coffee or a caffeinated beverage.”

Side effects and risks

L-theanine is generally considered safe and well-tolerated when taken at appropriate doses. In general, it’s recommended that you don’t exceed 500 milligrams (mg) a day. Most healthy adults can take between 200 mg and 500 mg a day.

But like any supplement, it may cause side effects, particularly at high doses. You can also simply try upping your tea intake to help get a good dose of L-theanine.

“If you’re trying to get your L-theanine in the form of black tea or green tea, then you’re going to have similar side effects like having too much caffeine,” notes Zumpano.

Some of the reported side effects of L-theanine include:

  • Headaches.
  • Dizziness.
  • Nausea.
  • Jitteriness.
  • Irritability.
  • Diarrhea.

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Is it safe?

It’s important to add that these L-theanine side effects are relatively uncommon and tend to be mild. L-theanine is generally considered safe for most people, but it’s always a good idea to talk to your healthcare provider before taking any new supplement, especially if you have any underlying health conditions or are taking medications. In addition, pregnant or breastfeeding (chestfeeding) people should also exercise caution when taking L-theanine, as there’s limited research on its safety in these populations.

“As of right now, the FDA has classified L-theanine as generally safe, but we don’t have specific guidelines on how to take it, just what the studies have shown,” adds Zumpano.

It’s also important to know that, like all supplements, the U.S. Food and Drug Administration (FDA) doesn’t review or regulate L-theanine products. This means no one checks what’s sold to ensure it’s safe and effective. If you’re planning to try L-theanine in supplement form, you should look for ahigh-quality version with no added fillers.

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Here’s What You Need To Know About L-Theanine (2024)

FAQs

Here’s What You Need To Know About L-Theanine? ›

People use L-theanine to improve mental function. It is also used for anxiety, mental impairment, stress, and other conditions, but there is no good scientific evidence to support these uses. Don't confuse theanine with another amino acid called threonine. These are not the same.

What are the negative side effects of L-theanine? ›

High doses on daily basis will lead to:
  • Lowering blood pressure (which may be beneficial to some people).
  • Appetite loss.
  • Diarrhea.>
  • Difficulty in concentration.
  • Headache.
  • Nausea.
  • Extreme high doses (29mg/kg/day) can cause liver toxicity.

Is it safe to take L-theanine every day? ›

L-theanine is generally considered safe and well-tolerated when taken at appropriate doses. In general, it's recommended that you don't exceed 500 milligrams (mg) a day. Most healthy adults can take between 200 mg and 500 mg a day. But like any supplement, it may cause side effects, particularly at high doses.

What to avoid when taking L-theanine? ›

L-theanine may interact with the following drugs and supplements:
  • drugs for the treatment of high blood pressure.
  • other supplements that lower blood pressure.
  • stimulants, such as those that doctors use to treat attention deficit hyperactivity disorder (ADHD)
  • supplements that contain caffeine.

What does L-theanine do for you? ›

l-theanine (γ-glutamylethylamide), an amino acid in green tea, has been shown to affect brain functions by relieving stress disorders, improving mood, and maintaining normal sleep. However, the cognitive functions for which theanine is effective are unclear.

Is L-theanine hard on your liver? ›

There is no evidence to suggest that L-theanine has adverse effects on liver function. However, if you have liver concerns or are taking medications that impact liver function, consult with your healthcare provider before using L-theanine.

Which is better, L-theanine or Ashwagandha? ›

In short, L-theanine is known for its calming effects on the mind and is often used to improve mental function, mood, and relaxation, while Ashwagandha is an adaptogen that helps the body manage the otherwise cascading effects of stress in your body and is used for a wide-ranging variety of physical and mental benefits ...

How long does it take for L-theanine to kick in? ›

However, the original claims relating to the calming effect of l-theanine show it is usually noted within 40–60 min after l-theanine ingestion at a dose of 50–200 mg. Effective dose of 200 mg of l-theanine in the present study to induce relaxation is well consistent with the work of Kobayashi et al.

What happens when you drink coffee with theanine? ›

Paired with caffeine, L-theanine may help increase focus and attention. A small study found that a combination of L-theanine (97 milligrams, or mg) and caffeine (40 mg) helped a group of young adults focus better during demanding tasks. A typical cup of coffee contains 95 mg of caffeine ( 4 , 5).

Does L-theanine deplete serotonin? ›

L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors.

What foods are high in theanine? ›

The greatest sources of L-theanine in our diets are green, black and white teas — but because most people don't drink very large quantities of tea on a daily basis, L-theanine supplements can be beneficial.

Is it better to take L-theanine in the morning or at night? ›

L-theanine can be taken at any time of day, including in the morning to help support healthy stress response and at night before bed to promote restful sleep.

Can you take magnesium and L-theanine together? ›

For most people, it should be safe to combine L-theanine and magnesium, as both are safe at reasonable doses. The pair aren't well studied together, but research does not indicate that taking them together would be a problem.

Does theanine affect the heart? ›

Researchers in one study found that doses of 250 mg and 400 mg of L-theanine greatly improved sleep in animals and humans (16). Also, 200 mg of L-theanine was shown to help reduce resting heart rate, pointing to its ability to promote relaxation (16).

Can L-theanine cause forgetfulness? ›

In a randomized controlled trial in patients with mild cognitive impairment, L-theanine taken with green tea extract for 16 weeks had no significant effect on memory and attention, though a trend for an improvement in memory was seen midway through the trial [1].

Is L-theanine safe for kidneys? ›

Moreover, L-theanine is also a bioactive compound with plenty of health benefits, including antioxidant, anti-inflammatory, neuroprotective, anticancer, metabolic regulatory, cardiovascular protective, liver and kidney protective, immune regulatory, and anti-obesity effects.

Does L-theanine affect the thyroid? ›

L-theanine

High levels of stress hormones can harm the thyroid. The amino acid L-theanine helps to reduce stress response activity in the body, balancing stress hormones and helping to protect thyroid function.

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